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匹配条件: “Rajeev Raghavan” ,找到相关结果约1225条。
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Syphilis and kidney disease: a case report and review of literature
Bashar Hannawi,Rajeev Raghavan
Nephrology Reviews , 2012, DOI: 10.4081/nr.2012.e10
Abstract: There has been a resurgence in the number of incident cases of syphilis in the United States. Syphilis can affect the kidney and usually causes a glomerular lesion with variable amounts of proteinuria. We present a case of a 24-year old African-American male who presented with both membranous glomerulonephritis and secondary syphilis. His kidney disease resolved after a course of penicillin. Recognizing the association of syphilis and proteinuria is important since antibiotic therapy generally results in complete recovery of the associated nephropathy.
Population, Ecology, and Threats to Two Endemic and Threatened Terrestrial Chelonians of the Western Ghats, India
Arun Kanagavel,Shiny M. Rehel,Rajeev Raghavan
ISRN Biodiversity , 2013, DOI: 10.1155/2013/341687
Abstract: The Western Ghats part of the Western Ghats-Sri Lanka hotspot harbors two endemic terrestrial chelonians, the Cochin forest cane turtle Vijayachelys silvatica and the Travancore tortoise Indotestudo travancorica. Population estimates as well as information on the scale and intensity of threats for these chelonians are largely unavailable. This study attempts to address these gaps for two hill ranges of the Western Ghats. Thirty random quadrats at eight forest ranges were surveyed for chelonians and their carapaces recording any found en route and also during opportunistic surveys. Three live V. silvatica and 38 I. travancorica were subsequently encountered and had overall densities of 0.006 and 0.03 individuals per hectare, respectively. These chelonians were found at quadrats with lower light intensity and soil temperature. Nine carapaces were found during the field surveys: seven the result of human consumption, one trapped in a pit, and another consumed by a wild animal. In addition to field surveys, household surveys in 26 indigenous and nonindigenous human settlements resulted in the observation of one V. silvatica and 38 I. travancorica including a carapace. Roads were surveyed to assess the threat they posed to chelonians, resulting in the observation of two I. travancorica road kills. Increased interactions and discussions between the management authorities and local communities need to be promoted if chelonian conservation is to improve in the landscape. 1. Introduction The Western Ghats (WG) region in India, part of the Western Ghats-Sri Lanka Biodiversity Hotspot is globally renowned for its diversity of endemic amphibian, reptile, and fish species [1–3]. The two endemic chelonian genera in the WG are represented by the Travancore tortoise (Indotestudo travancorica) and the Cochin forest cane turtle (Vijayachelys silvatica); both threatened with extinction [4, 5]. The cane turtle is listed as “Endangered” while the Travancore tortoise is “Vulnerable” in the IUCN Red List of Threatened Species [4, 5]. Of these sympatric, cryptic species, Travancore tortoises are known to be more widespread than cane turtles [6, 7]. The Travancore tortoise is found in rocky hills at elevations of 100–1000?m a.s.l. across the southern WG in a multitude of habitats, such as evergreen, semievergreen, bamboo, Lantana camara and Cromolarium glandulosum bushes, and rubber and teak plantations [8–12]. On the other hand, the Cochin forest cane turtle, known to be a habitat specialist associated with evergreen vegetation, has also been found in semievergreen, deciduous,
Potential for Community and Conservation Reserves in the Western Ghats, India
Arun Kanagavel,Shijo Joseph,Revati Pandya,Rajeev Raghavan
Asian Journal of Conservation Biology , 2013,
Abstract: Protected Areas represent the world’s economic and political commitment towards the conservation of biodiversity. The Western Ghats (WG) in peninsular India, part of the Western Ghats-Sri Lanka Hotspot has the highest human population density and population pressure in the world and is in need of urgent conservation attention. Community Reserves and Conservation Reserves are protected area systems in India which integrate local communities as well as private organisations into protected area management. The potential for Community and Conservation Reserves was evaluated at 25 reserve forests and privately owned/leased forest fragments at Kodaikanal, Theni and Valparai, which are limited-access areas in the human-dominated landscape of the southern WG. Data collection at each site, on a range of issues, was based upon the characteristics of local communities which would be central to the integration of resource-use, community participation and biodiversity conservation. The sites where local communities preferred to participate in protected area management were further prioritized through ranking them for the variables and index calculated. Sixteen potential, community and conservation reserves were subsequently identified and prioritised. An analysis of the perceptions, of forest department officials and conservation researchers, towards the establishment of such reserves revealed that they were unsure whether these reserve systems would be beneficial for biodiversity conservation.
The tragedy of the nature photography commons
Diogo Veríssimo,Arun Kanagavel,K. S Seshadri,Rajeev Raghavan
Asian Journal of Conservation Biology , 2013,
Abstract: EDITORIAL
Bortezomib in Kidney Transplantation
Rajeev Raghavan,Abdallah Jeroudi,Katafan Achkar,A. Osama Gaber,Samir J. Patel,Abdul Abdellatif
Journal of Transplantation , 2010, DOI: 10.1155/2010/698594
Abstract: Although current therapies for pretransplant desensitization and treatment of antibody-mediated rejection (AMR) have had some success, they do not specifically deplete plasma cells that produce antihuman leukocyte antigen (HLA) antibodies. Bortezomib, a proteasome inhibitor approved for the treatment of multiple myeloma (a plasma cell neoplasm), induces plasma cell apoptosis. In this paper we review the current body of literature regarding the use of this biological agent in the field of transplantation. Although limited experience with bortezomib may seem to show promise in the realm of transplant recipients desensitization and treatment of AMR, there is also experience that may suggest otherwise. Bortezomib's role in desensitization protocols and treatment of AMR will be defined better as more clinical data and trials become available.
Morphological and Genetic Evidence for Multiple Evolutionary Distinct Lineages in the Endangered and Commercially Exploited Red Lined Torpedo Barbs Endemic to the Western Ghats of India
Lijo John, Siby Philip, Neelesh Dahanukar, Palakkaparambil Hamsa Anvar Ali, Josin Tharian, Rajeev Raghavan, Agostinho Antunes
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069741
Abstract: Red lined torpedo barbs (RLTBs) (Cyprinidae: Puntius) endemic to the Western Ghats Hotspot of India, are popular and highly priced freshwater aquarium fishes. Two decades of indiscriminate exploitation for the pet trade, restricted range, fragmented populations and continuing decline in quality of habitats has resulted in their ‘Endangered’ listing. Here, we tested whether the isolated RLTB populations demonstrated considerable variation qualifying to be considered as distinct conservation targets. Multivariate morphometric analysis using 24 size-adjusted characters delineated all allopatric populations. Similarly, the species-tree highlighted a phylogeny with 12 distinct RLTB lineages corresponding to each of the different riverine populations. However, coalescence-based methods using mitochondrial DNA markers identified only eight evolutionarily distinct lineages. Divergence time analysis points to recent separation of the populations, owing to the geographical isolation, more than 5 million years ago, after the lineages were split into two ancestral stocks in the Paleocene, on north and south of a major geographical gap in the Western Ghats. Our results revealing the existence of eight evolutionarily distinct RLTB lineages calls for the re-determination of conservation targets for these cryptic and endangered taxa.
Bortezomib in Kidney Transplantation
Rajeev Raghavan,Abdallah Jeroudi,Katafan Achkar,A. Osama Gaber,Samir J. Patel,Abdul Abdellatif
Journal of Transplantation , 2010, DOI: 10.1155/2010/698594
Abstract: Although current therapies for pretransplant desensitization and treatment of antibody-mediated rejection (AMR) have had some success, they do not specifically deplete plasma cells that produce antihuman leukocyte antigen (HLA) antibodies. Bortezomib, a proteasome inhibitor approved for the treatment of multiple myeloma (a plasma cell neoplasm), induces plasma cell apoptosis. In this paper we review the current body of literature regarding the use of this biological agent in the field of transplantation. Although limited experience with bortezomib may seem to show promise in the realm of transplant recipients desensitization and treatment of AMR, there is also experience that may suggest otherwise. Bortezomib's role in desensitization protocols and treatment of AMR will be defined better as more clinical data and trials become available. 1. Introduction Kidney transplantation is the treatment of choice for most patients with stage five chronic kidney disease (CKD). The risk of death is less than half of that for dialysis patients regardless of the immunosuppression protocol used [1]. Furthermore, most recipients acknowledge improved quality of life. It is not surprising that the demand for donor kidneys continually outpaces the supply. The United Network for Organ Sharing (UNOS) has over 80,000 patients on the kidney transplant waiting list, many of whom are highly sensitized. Data obtained from the UNOS (2001–2008) showed that the rates of transplantation for living donor (LD) and deceased donor (DD) by panel reactive antibody (PRA) status are less than 16% per year for patients with PRAs of 10% to 80%, and less than 8% for patients with PRAs more than 80%. Thus, sensitized patients with any level of PRA are difficult to transplant and have longer waiting times on the transplant list [2]. Strategies for removing or decreasing preformed antibodies in these patients are termed desensitization. Literature review demonstrates 1-year allograft survival between 69% and 96% for desensitizieted patients [3]. The rejection risk for all patients in the first year post transplant is less than 12% based on the 2009 USRDS database [4]. Highly sensitized transplant recipients, regardless of the desensitization protocol used, are at increased risk for AMR. Both desensitization and AMR are managed with the similar therapeutic arsenal; however protocols are center-specific and there are no consensus guidelines [5]. The two desensitization protocols for which clinical efficacy has been demonstrated are high-dose IVIG or low-dose IVIG with either plasmapheresis (PP) or
Isolation of a High Affinity Neutralizing Monoclonal Antibody against 2009 Pandemic H1N1 Virus That Binds at the ‘Sa’ Antigenic Site
Nachiket Shembekar, Vamsee V. Aditya Mallajosyula, Arpita Mishra, Leena Yeolekar, Rajeev Dhere, Subhash Kapre, Raghavan Varadarajan, Satish Kumar Gupta
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055516
Abstract: Influenza virus evades host immunity through antigenic drift and shift, and continues to circulate in the human population causing periodic outbreaks including the recent 2009 pandemic. A large segment of the population was potentially susceptible to this novel strain of virus. Historically, monoclonal antibodies (MAbs) have been fundamental tools for diagnosis and epitope mapping of influenza viruses and their importance as an alternate treatment option is also being realized. The current study describes isolation of a high affinity (KD = 2.1±0.4 pM) murine MAb, MA2077 that binds specifically to the hemagglutinin (HA) surface glycoprotein of the pandemic virus. The antibody neutralized the 2009 pandemic H1N1 virus in an in vitro microneutralization assay (IC50 = 0.08 μg/ml). MA2077 also showed hemagglutination inhibition activity (HI titre of 0.50 μg/ml) against the pandemic virus. In a competition ELISA, MA2077 competed with the binding site of the human MAb, 2D1 (isolated from a survivor of the 1918 Spanish flu pandemic) on pandemic H1N1 HA. Epitope mapping studies using yeast cell-surface display of a stable HA1 fragment, wherein ‘Sa’ and ‘Sb’ sites were independently mutated, localized the binding site of MA2077 within the ‘Sa’ antigenic site. These studies will facilitate our understanding of antigen antibody interaction in the context of neutralization of the pandemic influenza virus.
Growth Stress Induced Tunability of Dielectric Constant in Thin Films
K. V. L. V. Narayanachari,Hareesh Chandrasekar,Amiya Banerjee,K. B. R. Varma,Rajeev Ranjan,Navakanta Bhat,Srinivasan Raghavan
Physics , 2015,
Abstract: It is demonstrated here that growth stress has a substantial effect on the dielectric constant of zirconia thin films. The correct combination of parameters - phase, texture and stress - is shown to yield films with high dielectric constant and best reported equivalent oxide thickness of 0.8 nm. The stress effect on dielectric constant is twofold, firstly, by the effect on phase transitions and secondly by the effect on interatomic distances. We discuss and explain the physical mechanisms involved in the interplay between the stress, phase changes and the dielectric constant in detail.
Significance of Impurity Mineral Identification in the Value Addition of Kaolin – A Case Study with Reference to an Acidic Kaolin from India  [PDF]
S. Ramaswamy, P. Raghavan
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.1011077
Abstract: Kaolin or china clay is a versatile industrial mineral with wide technological applications and is abundantly available in India. The major mineral in kaolin is kaolinite (Al2O3.2SiO2.2H2O). The common ancillary / impurity minerals occurring with kaolin include parent rocks like feldspar and mica, quartz, ferruginous, titanoferrous and carbonaceous materials. The most deleterious impurities in kaolin are iron minerals which imparts colour to the white kaolin. Iron exists as oxides, hydroxides, oxy hydroxides, sulphides and carbonates along with iron stained quartz/anatase and mica in kaolin. Kaolin finds extensive applications in paper, paint, rubber, ceramics, plastics etc. One of the highest value additions for kaolin is as pigment in paper and paint industries. The optical properties are important for pigment applications and removal of the iron impurity is very important to improve this property. Extensive research has been carried out on the nature of iron impurities present in kaolin, which leads to the conclusion that iron is present as a part of the kaolinite or ancillary mineral (mica or titania) structure, which can be termed as “structural iron” or as independent iron minerals such as oxides, hydroxides, oxyhydroxides, sulphides and carbonates, which can be termed as “free iron” [1]. The present paper discusses the iron speciation studies carried out on a typical china clay sample collected from Koraput district of Orissa State in the Union of India. Studies have shown that the major impurity mineral species is in “pyritic” (Iron sulphide) form along with other hydroxides, oxyhydoxides and oxides of Iron. Presence of limonite is also observed in the sample. The identification/quantification of the impurity minerals have played a crucial role in the selection / modification and sequentialisation of beneficiation processes and subsequent processing studies have shown that the sample can be value added to ceramic grade.
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