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匹配条件: “Daniel McLaughlin” ,找到相关结果约33073条。
Diamondback terrapin (Malaclemys terrapin terrapin) research and conservation project on the Atlantic coast of Southern New Jersey, USA
Roger Wood,Daniel McLaughlin,David Kays
Asian Journal of Conservation Biology , 2012,
Traumatic Brain Injury in the Military  [PDF]
Aden McLaughlin
Open Journal of Modern Neurosurgery (OJMN) , 2013, DOI: 10.4236/ojmn.2013.32005

Traumatic brain injury (TBI) is a devastating and extraordinarily expensive entity. It is becoming increasingly burdensome in the military setting with societal costs of managing the sequelae of TBI running into the billions of dollars (US$) each year. Increasing awareness among non-neurosurgical medical personnel of the pathophysiology of TBI and rapid and appropriate assessment, triage and treatment will increase the likelihood of a better outcome in any given head injured patient. Careful attention to prevention of secondary injury is vital if further decline following the initial insult is to be achieved. Early and repeated neurological assessment, and aggressive management of intracranial hypertension and disorders affecting airway and cardiorespiratory systems are the mainstay of managing moderate to severe TBI. This management may involve medical and surgical options and often requires battlefield assessment prior to aeromedical evacuation. The unique profile and epidemiology of TBI in the military, necessitates ongoing research into primary prevention and appropriate, cost-effective means of assessing and treating these often debilitating injuries. Improvements in the prevention and care of these individuals will lead to enormous individual and societal gains.

Correcting for Interstellar Scattering Delay in High-precision Pulsar Timing: Simulation Results
Nipuni Palliyaguru,Daniel Stinebring,Maura McLaughlin,Paul Demorest,Glenn Jones
Physics , 2015, DOI: 10.1088/0004-637X/815/2/89
Abstract: Light travel time changes due to gravitational waves may be detected within the next decade through precision timing of millisecond pulsars. Removal of frequency-dependent interstellar medium (ISM) delays due to dispersion and scattering is a key issue in the detection process. Current timing algorithms routinely correct pulse times of arrival (TOAs) for time-variable delays due to cold plasma dispersion. However, none of the major pulsar timing groups correct for delays due to scattering from multi-path propagation in the ISM. Scattering introduces a frequency-dependent phase change in the signal that results in pulse broadening and arrival time delays. Any method to correct the TOA for interstellar propagation effects must be based on multi-frequency measurements that can effectively separate dispersion and scattering delay terms from frequency-independent perturbations such as those due to a gravitational wave. Cyclic spectroscopy, first described in an astronomical context by Demorest (2011), is a potentially powerful tool to assist in this multi-frequency decomposition. As a step toward a more comprehensive ISM propagation delay correction, we demonstrate through a simulation that we can accurately recover impulse response functions (IRFs), such as those that would be introduced by multi-path scattering, with a realistic signal-to-noise ratio. We demonstrate that timing precision is improved when scatter-corrected TOAs are used, under the assumptions of a high signal-to-noise and highly scattered signal. We also show that the effect of pulse-to-pulse "jitter" is not a serious problem for IRF reconstruction, at least for jitter levels comparable to those observed in several bright pulsars.
Primary CNS T-Cell Lymphoma: A Case Report on a Solitary Cerebellar Lesion and Review of Current Relevant Literature  [PDF]
Aden McLaughlin, Sharon Gabizon
Open Journal of Modern Neurosurgery (OJMN) , 2013, DOI: 10.4236/ojmn.2013.32004

Primary central nervous system lymphoma of T-cell lineage (PCNSTL) is an extremely rare entity, with relatively few cases reported in the literature. Presented here is a case of a 44-year-old, HIV negative woman found to have a solitary cerebellar lesion following presentation to the Emergency Department with a fall. The lesion responded to emergent dexamethasone and was followed with serial MRI imaging, which continued to show lesion regression. The lesion was shown to have recurred on MRI 14 months post-presentation and found to be T-cell lymphoma following immunophenotyping and TCR gene rearrangement studies of tissue specimen obtained via excisional biopsy.

Spectroscopic Discrimination of Bone Samples from Various Species  [PDF]
Gregory McLaughlin, Igor K. Lednev
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.32023
Abstract: Determining the species of origin of skeletal remains is critical in a forensic and anthropologic context. However, there are very few methods that use a chemical approach to assist in this determination. In this study, Raman spectroscopy was used to discriminate bone samples originating from four different species (bovine, porcine, turkey and chicken). Spectra were obtained using a near infrared laser at 785-nm. All spectra were combined in a single matrix and processed using partial least squares discriminate analysis (PLS-DA) with leave-one-out cross-validation. Three com-ponents were found to adequately describe the system. The first two components which contributed over 85% of spec-tral data was seen to completely separate the four species of origin in a two dimensional scores plot. A 95% confidence interval was draw around score points of each species class with very slight overlap. The first two components were seen to have large contributions from bioapatite and collagen, the main components of bone. This study serves as a preliminary investigation to evaluate the effectiveness of Raman spectroscopy to discriminate the species of origin of bone tissue.
Nuclear Odontogenic Ameloblast-Associated Protein (ODAM) Correlates with Melanoma Sentinel Lymph Node Metastasis  [PDF]
Sagar S. Gandhi, Daniel P. Kestler, Charles T. Bruker, James M. McLaughlin, Robert E. Heidel, Sabina Siddiqui, James S. Foster, Keith D. Gray, John Bell, Alan Solomon, James Lewis
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.48151

We have examined primary tumor sections from melanoma patients by immunohistochmistry (IHC) for the presence of the odontogenic ameloblast-associated protein (ODAM). Within these patient tissues we have observed a correlation of nuclear ODAM staining in the primary tumors with sentinel lymph node (SLN) metastasis. Surgically, SLN invasion in melanoma is considered an important indicator of more aggressive, invasive melanoma and to date there are limited biomarkers which strongly correlate with metastatic disease. The observation that ODAM staining in melanoma associates with SLN invasion may have important prognostic implications which could assist in the management of melanoma. Notably, ODAM expression may correlate with pathway-signaling we have previously reported to be affected by ectopic ODAM expression in cultured melanoma and breast cancer cell lines.

Assembling the human genome - for free
Andrew McLaughlin
Genome Biology , 2000, DOI: 10.1186/gb-spotlight-20000823-01
Senior scientists promise to boycott journals
Andrew McLaughlin
Genome Biology , 2000, DOI: 10.1186/gb-spotlight-20001113-02
Abstract: So far more than 160 scientists have signed an online petition that encourages scientists from around the world to pledge their support to the campaign. The petition will be published in its final version in May next year with a proposed boycott beginning in September 2001. Included in the list of signatories are PubMed Central co-founder Harold Varmus - president of the Memorial Sloan-Kettering Cancer Center - and Stanford geneticist David Botstein.The supporters of the initiative believe that it will "vastly increase the accessibility and utility of the scientific literature, enhance scientific productivity, and catalyze integration of the disparate communities of knowledge and ideas in biomedical sciences." Campaigners aim to prevent the published record of scientific research, much of it paid for with public funds amounting to tens of billions of dollars a year, from being "permanently controlled and monopolized by publishers." The organizers of the initiative hope to make research articles freely available through an international online public library, once publishers have had a six month "lease" to recover their costs and earn a fair return for their contributions to the publication process.Commenting on the initiative in the Library Journal Academic Newswire, Karen Hunter, senior vice president of Reed Elsevier's ScienceDirect database was skeptical, "I don't think they'll find much support", she said. Although sympathetic to the issue of accessing research already archived by publishers, she says that negotiations within the publishing industry should go some way towards alleviating the problem. Hunter also suggested a problem of funding a resource to collect research in one central, free library, "Who would fund it? Government?"Another person who is skeptical about the initiative is Stevan Harnad, professor of cognitive science at Southampton University and one of the world's leading advocates for freeing the refereed journal literature online through self
Cracking cell signalling by sharing - not publishing
Andrew McLaughlin
Genome Biology , 2000, DOI: 10.1186/gb-spotlight-20000921-01
Abstract: The AFCS, launched last week, is being supported by a $25 million grant from the US National Institute of General Medical Sciences (NIGMS) together with backing from private industry. Fifty investigators from twenty universities in North America and the UK will form the core contingent of the research program together with many of the world's cell signalling community who are invited to join the AFCS program. The research effort in the AFCS's six laboratories will concentrate on examining how modular signal pathways interact with each other. In particular, the researchers will focus on two cells that display interesting and important G-protein related phenomena: the B lymphocyte and the cardiac myocyte. Gilman, who was awarded a Nobel Prize in 1994 for his work with G-proteins, will head the project from the University of Texas Southwestern Medical Center at Dallas. The ultimate result, suggests Gilman, could be the development of a 'virtual cell', a computer program that would mimic the function of a cell. "A virtual cell would be a wonderful way to understand what the optimal point would be to place a drug to achieve a specific goal in a specific patient in a specific kind of disease," says Gilman.As research from the laboratories is completed and validated by the steering community, new discoveries, findings or theories will be posted onto a 'molecule page' linked to the AFCS website through Internet2 - the new university-based Internet that will allow the rapid transmission of large amounts of information. The AFCS is hoping that researchers will come to see having their results posted on a molecule page as being equivalent to publishing in an academic journal. The investigators and members of AFCS will then communicate through the website, using discussion groups and video conferences to discuss the findings. In posting to the molecule pages, investigators and their universities will instantly relinquish any intellectual property rights they may have for the wo
The Ethics of Exploitation
Paul McLaughlin
Studia Philosophica Estonica , 2008,
Abstract: Philosophical inquiry into exploitation has two major deficiencies to date: it assumes that exploitation is wrong by definition; and it pays too much attention to the Marxian account of exploitation. Two senses of exploitation should be distinguished: the ‘moral’ or pejorative sense and the ‘non-moral’ or ‘non-prejudicial’ sense. By demonstrating the conceptual inadequacy of exploitation as defined in the first sense, and by defining exploitation adequately in the latter sense, we seek to demonstrate the moral complexity of exploitation. We contend, moreover, that moral evaluation of exploitation is only possible once we abandon a strictly Marxian framework and attempt, in the long run, to develop an integral ethic along Godwinian lines.

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