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匹配条件: “ Rose-Mary Boustany” ,找到相关结果约7224条。
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Large-Scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System
John F. Staropoli, Larissa Haliw, Sunita Biswas, Lillian Garrett, Sabine M. H?lter, Lore Becker, Sergej Skosyrski, Patricia Da Silva-Buttkus, Julia Calzada-Wack, Frauke Neff, Birgit Rathkolb, Jan Rozman, Anja Schrewe, Thure Adler, Oliver Puk, Minxuan Sun, Jack Favor, Ildikó Racz, Raffi Bekeredjian, Dirk H. Busch, Jochen Graw, Martin Klingenspor, Thomas Klopstock, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Edith Lopez, Hayat Harati, Eric Hill, Daniela S. Krause, Jolene Guide, Ella Dragileva, Evan Gale, Vanessa C. Wheeler, Rose-Mary Boustany, Diane E. Brown, Sylvie Breton, Klaus Ruether, Valérie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Susan L. Cotman
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038310
Abstract: Cln3Δex7/8 mice harbor the most common genetic defect causing juvenile neuronal ceroid lipofuscinosis (JNCL), an autosomal recessive disease involving seizures, visual, motor and cognitive decline, and premature death. Here, to more thoroughly investigate the manifestations of the common JNCL mutation, we performed a broad phenotyping study of Cln3Δex7/8 mice. Homozygous Cln3Δex7/8 mice, congenic on a C57BL/6N background, displayed subtle deficits in sensory and motor tasks at 10–14 weeks of age. Homozygous Cln3Δex7/8 mice also displayed electroretinographic changes reflecting cone function deficits past 5 months of age and a progressive decline of retinal post-receptoral function. Metabolic analysis revealed increases in rectal body temperature and minimum oxygen consumption in 12–13 week old homozygous Cln3Δex7/8mice, which were also seen to a lesser extent in heterozygous Cln3Δex7/8 mice. Heart weight was slightly increased at 20 weeks of age, but no significant differences were observed in cardiac function in young adults. In a comprehensive blood analysis at 15–16 weeks of age, serum ferritin concentrations, mean corpuscular volume of red blood cells (MCV), and reticulocyte counts were reproducibly increased in homozygous Cln3Δex7/8 mice, and male homozygotes had a relative T-cell deficiency, suggesting alterations in hematopoiesis. Finally, consistent with findings in JNCL patients, vacuolated peripheral blood lymphocytes were observed in homozygous Cln3Δex7/8 neonates, and to a greater extent in older animals. Early onset, severe vacuolation in clear cells of the epididymis of male homozygous Cln3Δex7/8 mice was also observed. These data highlight additional organ systems in which to study CLN3 function, and early phenotypes have been established in homozygous Cln3Δex7/8 mice that merit further study for JNCL biomarker development.
La interrupcion voluntaria e informada del embarazo
Madden Arias,Rose Mary;
Medicina Legal de Costa Rica , 2006,
Abstract: this article analyses the voluntary interruption of pregnancy from the feminist, along with a legal, point of view, parting from the fact that one of the forms of violence against women, and particularly, against their reproductive rights, is the legal, cultural, social, or religious impossibilities to decide informed and voluntarily the interruption of pregnancy. this way, the article studies the regulations imposed by the penal code regarding abortion and how they are forms of violence against women.
La interrupcion voluntaria e informada del embarazo Voluntary and informed interruption of pregnancy
Rose Mary Madden Arias
Medicina Legal de Costa Rica , 2006,
Abstract: Este artículo trata la interrupción voluntaria del embarazo desde la perspectiva feminista, y con un enfoque legal, y parte del hecho que una de las formas de violencia contra las mujeres, y en particular, del ejercicio pleno de sus derechos reproductivos, es la imposibilidad legal, cultural, social o religiosa de decidir voluntaria e informada la interrupción del embarazo. Así, el artículo analiza la normativa recogida en el Código Penal sobre el aborto y cómo estos tipos penales son formas de violencia contra las mujeres. This article analyses the voluntary interruption of pregnancy from the feminist, along with a legal, point of view, parting from the fact that one of the forms of violence against women, and particularly, against their reproductive rights, is the legal, cultural, social, or religious impossibilities to decide informed and voluntarily the interruption of pregnancy. This way, the article studies the regulations imposed by the Penal Code regarding abortion and how they are forms of violence against women.
A qualidade e as exigências do mercado de tangerinas
Pio Rose Mary
Revista Brasileira de Fruticultura , 2003,
Abstract:
Evaluation and Management of Massive Endotracheal Hemorrhage in Pediatric Patients: A Case Report and Review of Literature  [PDF]
Cory Vaughn, Mona Shete, Rose Mary Stocks, Jerome Thompson
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2013, DOI: 10.4236/ijohns.2013.26049
Abstract:

Massive hemoptysis is a frightening and life-threatening event in children. Prompt, aggressive evaluation and management are necessary. The most common cause of hemoptysis in a pediatric patient is infectious, but other various etiologies including tracheotomy related problems, cystic fibrosis, bronchiectasis, congenital anomalies of the cardiopulmonary vasculature and suction trauma must be considered as well. Presented is a report of a case of acute, massive endotracheal hemorrhage with multiple methods of management including balloon tamponade, highly selective embolization, and mainstem occlusion. This case is an addition to our previously reported case series of nine pediatric patients with massive pulmonary hemorrhage. Various diagnostic and management techniques of hemoptyis in pediatric patients are discussed with an extensive review of the literature.

Valuing the person’s story: Use of life story books in a continuing care setting
Teresa Wills,Mary Rose Day
Clinical Interventions in Aging , 2008,
Abstract: Teresa Wills, Mary Rose DayCatherine McAuley School of Nursing and Midwifery, University College Cork, IrelandAbstract: There is an increasing focus on promoting person-centred systems across continuing care settings, emphasizing the need to enhance the quality of life of older adults. Life story books (LSB) can provide a holistic view of older adults, promote relationship-centred care and enhance person-centred care. The process of developing LSB involve collecting and recording aspects of a person’s life both past and present. The purpose of this study was to engage residents in developing life story books in a nursing home setting and then to explore the narratives and documented life story books with residents and their families. A qualitative descriptive exploratory design was utilized for the study. Five residents and three family carers participated. Focus groups were tape recorded and thematically analyzed and a review of the LSB was conducted. The central themes from the data analysis related to the social construction of people’s lives, social roles and religious values, relationships and loss, and sense of self.Keywords: life story
An exploration of knowledge, attitudes and advice given by health professionals to parents in Ireland about the introduction of solid foods. A pilot study
Claire Allcutt, Mary-Rose Sweeney
BMC Public Health , 2010, DOI: 10.1186/1471-2458-10-201
Abstract: A mixed-methods approach was used for the research, commencing with a multi-disciplinary focus group to guide and develop a questionnaire. Questionnaires were then distributed in a postal survey to General Practitioners (GPs) (n 179), Practice Nurses (PNs) (n 121), Public Health Nurses (PHNs) (n 107) and Community Dieticians (CDs) (n 8).The results indicate varying levels of knowledge of official weaning recommendations and a variety of advice practices. CDs and PHNs acknowledged a clear role in providing weaning advice while demonstrating high confidence levels in providing this advice. However, 19% of PNs and 7% of GP respondents did not acknowledge that they have a role in providing weaning advice to parents; even though Health Service Executive (HSE) written literature given to parents states that they should seek information from PNs and GPs.Small pockets of misinformation about the introduction of solid foods persist amongst health professionals which may lead to inconsistent advice for parents. Further research is needed.The first months of an infant's life are characterised by rapid growth and development, with a corresponding period of parental learning and upheaval. Much early parental anxiety and uncertainty concerns infant feeding, with new parents seeking advice from family and friends, from books and the media, as well as from the health professionals who have responsibility to provide evidence-based, best practice advice. There is much concern, confusion and controversy around the introduction of solid foods due to changing guidelines and evidence about the health implications of the type and timing of solid foods.Weaning is defined as the introduction of the first solid foods to infants. It is widely believed that there are significant health implications from the introduction of inappropriate solid foods to infants during weaning, including the risk of eczema, asthma, allergy and obesity. Prior to 2001 the World Health Organisation (WHO) recommended
Florescimento e frutifica??o em bambu
Azzini, Anísio;Aranha, Condorcet;Pio, Rose Mary;
Bragantia , 1982, DOI: 10.1590/S0006-87051982000100018
Abstract: in february 1977 the flowering and seeding of bamboo specie melocanna baccifera kurz was observed at the campinas experimental station. the morphological and botanical characteristics observed showed that the material belongs to the above mentioned specie.
Beyond the informed consent procedure: continuing consent in human research
Mueller,Mary-Rose; Instone,Susan;
Ciência & Saúde Coletiva , 2008, DOI: 10.1590/S1413-81232008000200013
Abstract: an ethnographic field study about informed consent in hepatitis c clinical trials provides insight into how changes in protocol requirements and patient health status triggered the actions and decisions of researchers and human subjects during the conduct of these trials. u.s. federal guidelines recommend that informed consent should be conceptualized as more than a one-time event. rather, a process of continuing consent should be the standard but little is understood about how exactly this process should unfold. we used a proposed typology of continuing consent to frame our analysis and were able to document that only some of the proposed types took place at the site of our study. the most frequent practice involved the researchers' re-consent of their subjects for major protocol revisions. only one subject dissented and chose to withdraw even though he was technically eligible to continue in the study. two other types of continuing consent were not observed. we discovered an additional type of continuing consent not described in the typology whereby subjects gave implied consent through their cooperation and adherence to the on-going requirements of the protocols. implications for the informed consent process and the need for further research are presented.
Influência da poliniza??o sobre o número de sementes do tangor-'Murcote'
AZEVEDO, FERNANDO ALVES DE;PIO, ROSE MARY;
Revista Brasileira de Fruticultura , 2002, DOI: 10.1590/S0100-29452002000200037
Abstract: the objective of this work wasstudy the influence of pollination on seeds production of'murcott' tangor. the experiment was carried out in the centro de citricultura sylvio moreira/iac, cordeirópolis, sp, brazil, in 1999/2000 season. flowers of 'murcott' tangor plants, 13 years old, were treated as follows: 1. pollination with 'valencia' sweet orange; 2. pollination with 'natal' sweet orange; 3. pollination with 'pera' sweet orange; 4. pollination with 'ponkan' madarin; 5. isolation of complete flower; 6. isolation of emasculated flower; 7. check (free flower). in october of 2000, the fruits were harvested. the greatest percentage of harvested fruits was obtained in the treatments with 'natal' sweet orange (20%) and 'valencia' sweet orange (16%). no fruits were obtained in treatment 6, suggesting that this tangor doesn't develop partenocarpic fruits. an increase of seeds occurred in treatments 1 (12/fruit) and 2 (10,3/fruit) in relation to the check (9,1/fruit) and a reduction occurred in treatments 3 (6,8/fruit), 4 (6,3/fruit) and 5 (5,9/fruit), what makes the influence of pollination in this fruit characteristics evident. no significant differences were observed in acidity and soluble solids of the juice. these results suggest that 'murcott' tangor plantings could be planted next or intercalated to 'pera' sweet orange and'ponkan' mandarin plantings, or planted isolated by windbreaks.
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