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匹配条件: “ Diane E. Brown” ,找到相关结果约172302条。
Chronic Murine Typhoid Fever Is a Natural Model of Secondary Hemophagocytic Lymphohistiocytosis
Diane E. Brown,Melissa W. McCoy,M. Carolina Pilonieta,Rebecca N. Nix,Corrella S. Detweiler
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009441
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a hyper-inflammatory clinical syndrome associated with neoplastic disorders especially lymphoma, autoimmune conditions, and infectious agents including bacteria, viruses, protozoa and fungi. In both human and veterinary medicine, hemophagocytic histiocytic disorders are clinically important and frequently fatal. HLH in humans can be a primary (familial, autosomal recessive) or secondary (acquired) condition, with both types generally precipitated by an infectious agent. Previously, no mouse model for secondary HLH has been reported. Using Salmonella enterica serotype Typhimurium by oral gavage to mimic naturally-occurring infection in Sv129S6 mice, we characterized the clinical, hematologic and morphologic host responses to disease thereby describing an animal model with the clinico-pathologic features of secondary HLH as set forth by the Histiocyte Society: fever, splenomegaly, cytopenias (anemia, thrombocytopenia), hemophagocytosis in bone marrow and spleen, hyperferritinemia, and hypofibrinogenemia. Disease severity correlates with high splenic and hepatic bacterial load, and we show disease course can be monitored and tracked in live animals. Whereby secondary HLH is known to occur in human patients with typhoid fever and other infectious diseases, our characterization of a viable natural disease model of secondary HLH offers an important means to elucidate pathogenesis of poorly understood mechanisms of secondary HLH and investigation of novel therapies. We characterize previously unreported secondary HLH in a chronic mouse model of typhoid fever, and novel changes in hematology including decreased tissue ferric iron storage that differs from classically described anemia of chronic disease. Our studies demonstrate S. Typhimurium infection of mice is a natural infectious disease model of secondary HLH that may have utility for elucidating disease pathogenesis and developing novel therapies.
Viral Encephalomyelitis
Diane E. Griffin
PLOS Pathogens , 2011, DOI: 10.1371/journal.ppat.1002004
Ancient Maya Regional Settlement and Inter-Site Analysis: The?2013 West-Central Belize LiDAR Survey
Arlen F. Chase,Diane Z. Chase,Jaime J. Awe,John F. Weishampel,Gyles Iannone,Holley Moyes,Jason Yaeger,M. Kathryn Brown,Ramesh L. Shrestha,William E. Carter,Juan C. Fernandez Diaz
Remote Sensing , 2014, DOI: 10.3390/rs6098671
Abstract: During April and May 2013, a total of 1057 km 2 of LiDAR was flown by NCALM for a consortium of archaeologists working in West-central Belize, making this the largest surveyed area within the Mayan lowlands. Encompassing the Belize Valley and the Vaca Plateau, West-central Belize is one of the most actively researched parts of the Maya lowlands; however, until this effort, no comprehensive survey connecting all settlement had been conducted. Archaeological projects have investigated at least 18?different sites within this region. Thus, a large body of archaeological research provides both the temporal and spatial parameters for the varied ancient Maya centers that once occupied this area; importantly, these data can be used to help interpret the collected LiDAR data. The goal of the 2013 LiDAR campaign was to gain information on the distribution of ancient Maya settlement and sites on the landscape and, particularly, to determine how the landscape was used between known centers. The data that were acquired through the 2013 LiDAR campaign have significance for interpreting both the composition and limits of ancient Maya political units. This paper presents the initial results of these new data and suggests a developmental model for ancient Maya polities.
The Common Oceanographer: Crowdsourcing the Collection of Oceanographic Data
Federico M. Lauro ,Svend Jacob Senstius,Jay Cullen,Russell Neches,Rachelle M. Jensen,Mark V. Brown,Aaron E. Darling,Michael Givskov,Diane McDougald,Ron Hoeke,Martin Ostrowski,Gayle K. Philip,Ian T. Paulsen,Joseph J. Grzymski
PLOS Biology , 2014, DOI: 10.1371/journal.pbio.1001947
The Basics of Alcohol Screening, Brief Intervention and Referral to Treatment in the Emergency Department
Vaca, Federico E,Winn, Diane
Western Journal of Emergency Medicine : Integrating Emergency Care with Population Health , 2007,
Abstract: Nearly eight million emergency department (ED) visits are attributed to alcohol every year in the United States. A substantial proportion is due to trauma. In 2005, 16,885 people were killed as a result of alcohol-related motor vehicle crashes. Patients with alcohol-use problems (AUPs) are not only more likely to drive after drinking but are also at greater risk for serious alcohol-related illness and injury. Emergency departments have an important and unique opportunity to identify these patients and intervene during the “teachable moment” of an ED visit. The American College of Emergency Physicians, Emergency Nurses Association, American College of Surgeons-Committee on Trauma, American Public Health Association, and the National Highway Traffic Safety Administration, have identified Alcohol Screening, Brief Intervention and Referral to Treatment (SBIRT) as a pivotal injury and illness-prevention strategy to improve the health and well-being of ED patients. We provide a general overview of the basis and need for integrating SBIRT into EDs. Models of SBIRT, as well as benefits and challenges to its implementation, are also discussed.
The Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH) can measure the impairment, activity limitations and participation restriction constructs from the International Classification of Functioning, Disability and Health (ICF)
Diane Dixon, Marie Johnston, Margaret McQueen, Charles Court-Brown
BMC Musculoskeletal Disorders , 2008, DOI: 10.1186/1471-2474-9-114
Abstract: Twenty-four judges used the method of Discriminant Content Validation to allocate the 38 items of the DASH to the theoretical definition of one or more ICF outcome. One-sample t-tests classified each item as measuring, impairment, activity limitations, participation restrictions, or a combination thereof.The DASH contains items able to measure each of the three ICF outcomes with discriminant validity. The DASH contains five pure impairment items, 19 pure activity limitations items and three participation restriction items. In addition, seven items measured both activity limitations and participation restrictions.The DASH can measure the three health outcomes identified by the ICF. Consequently the DASH could be used to examine the impact of trauma and subsequent interventions on each health outcome in the absence of measurement confound.Fracture of the wrist is a common injury and is especially prevalent in older post-menopausal women. Wrist fracture is associated with variable outcome, for example, approximately 50% of cases fail to recover pre-operative function [1] and 20% of patients report moderate to severe pain at 6 month post-fracture [2]. A recent series of Cochrane reviews of the effectiveness of commonly applied interventions for wrist fracture have highlighted the continued unsatisfactory outcome for many patients [3]. Further, there is an association between wrist fracture and long-term disability and increased risk of dependency [4]. Any measure of outcome from wrist fracture needs to be able to index the impact of fracture, not only on the impairment itself but also on the level of associated disability.The WHO identifies three health outcomes in its International Classification of Functioning Disability and Health (ICF) taxonomy of the consequences of disease, namely, impairments (I), activity limitations (A) and restrictions in social participation (P) [5] (see Table 1 for definitions). In accordance with the ICF, a complete assessment of outcome fo
Obesity communication among patients by health professionals: Findings from the Weight Care Project  [PDF]
S. Anne Moorhead, Vivien E. Coates, Alison M. Gallagher, Geraldine Nolan, Kathy Murphy, Diane E. Hazlett
Health (Health) , 2013, DOI: 10.4236/health.2013.58A3015
Abstract: Obesity is on the increase worldwide and is a major global public health problem. In an increasingly obesogenic environment, it’s important that health professionals are equipped to identify and address obesity issues within their clinical practice. As part of the Weight Care Project, the aim of this study was to explore the obesity-related communication issues for primary care and community-based health professionals. The study design was a quantitative survey, which was completed by 382 primary care and community-based health professionals across Northern Ireland and Republic of Ireland working with adults and children. Key findings included that the majority of the health professionals (86%) recognized having a role in giving obesity advice, acknowledged that in clinical practice communication of obesity messages is both complex and challenging (81%), and reported difficulty in sensitively addressing obesity issues (27%). The health professionals surveyed stated that they communicate obesity messages to their patients using a range of different methods, mainly verbally to individuals, leaflets and factsheets. Numerous benefits of communicating obesity messages were reported; the main one was interacting with patients to build trust. Identified barriers to commu

Introduction to Forensic Dentistry Continuing Education Course  [PDF]
Diane Osborne
Forensic Medicine and Anatomy Research (FMAR) , 2013,
Abstract: This course is an introduction to the basics of forensic dentistry beginning with its historical origins to modern advancements. After an introduction to basic principles, application of this information will be demonstrated in current cases, training in mass fatalities and participation in a mass fatality workshop scenario using dry skull remains. Time permitting, a tour of the Las Vegas Coroner’s Office will be available.
Problems of health insurance coverage and health care in the United States: public and private solution strategies
Brown, E. Richard;
Cadernos de Saúde Pública , 1992, DOI: 10.1590/S0102-311X1992000300007
Abstract: a nearly universal consensus has developed in the united states that the current health care financing system is a failure. the system has been unable to control the continuing rapid rise in health care costs (by far, the highest in the world), and it has been unable to stem the growing population that has no health insurance coverage (at least 36 million people). there is nearly universal political agreement that government must provide health insurance to a far greater share of the population than ever before. the political debate now focuses on whether this expanded government role should supplement the private insurance system with an enlarged public program covering those left out of private insurance coverage, or replace private insurance with a universal government health insurance program covering the entire population.
Emotional intelligence and locus of control of adult patients with breast cancer receiving treatment
O Brown, E Swartz
South African Family Practice , 2012,
Abstract: Background: This article investigates emotional intelligence and locus of control in an adult breast cancer population receiving treatment. Gaining insight into these constructs will contribute to improving breast cancer patients’ psychological well-being and to reducing physical vulnerability to disease before and during treatment. Method: The researcher used an exploratory, descriptive and correlational approach. Nonprobability purposive sampling was employed. Sixty-seven breast cancer patients receiving treatment participated in the research. A biographical questionnaire, the Schutte Emotional Intelligence Scale, and the Rotter Internal-External Locus of Control Scale were used to measure the constructs explored in this article. Descriptive and inferential statistics were used to analyse the data. Results: The sample yielded above-average levels of emotional intelligence and an internal locus of control. The results indicate a statistically and practically significant negative correlation between emotional intelligence and locus of control. The significant association found between higher and lower emotional intelligence groups and internal and external locus of control groups also confirmed these results. Conclusion: Having an understanding of the psychosocial variables that impact on individuals diagnosed with a chronic illness, in this case breast cancer, can assist interventionists working in the field of positive psychology. While the stressors and challenges that breast cancer patients face are well documented, this article highlights the strength factors emotional intelligence and locus of control as important mediators in the treatment and management of breast cancer.

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